Key result
High-throughput planar patch clamp enables ion current and action potential measurement in human iPSC-derived cardiomyocytes.
Why the study?
The use of hiPSC-CMs in drug development and patient treatment has been limited by the lack of applicable high-throughput patch-clamp methods suited to successful hiPSC-CM measurement.
A new protocol using planar patch-clamp technology allows for high-throughput measurement of ion channel currents in hiPSC-CMs, addressing limitations of traditional low-throughput methods.
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May enable scalable ion channel phenotyping in hiPSC-CM models; leaves open clinical translation pending prospective validation.
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Seibertz et al. (2026) studied Cardiac myocytes (hiPSC-CM). High-throughput planar patch clamp was evaluated. A modular high-throughput planar patch clamp method enables the measurement of ion channel currents and action potentials in human induced pluripotent stem cell-derived cardiomyocytes.
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