Why the study?
Current arrhythmic risk stratification requires proper implementation and an integrated evaluation to predict arrhythmic risk and discriminate competing risks between heart failure-related events and life-threatening arrhythmias in NICM.
Multiparametric risk stratification beyond ejection fraction, incorporating genetics and reverse remodeling prediction, is proposed to improve arrhythmic risk assessment in non-ischaemic dilated cardiomyopathy.
May support integrated genetic and remodeling assessment for arrhythmic risk in NICM; leaves open prospective validation before practice adoption.
mutations) appears fundamental for proper implementation of the current arrhythmic risk stratification. Finally, a novel approach focused on both arrhythmic risk and prediction of left ventricular reverse remodelling during follow-up might be useful for effective multiparametric and dynamic arrhythmic risk stratification in NICM. In the future, a complete and integrated evaluation might be mandatory to implement arrhythmic risk prediction in patients with NICM and to discriminate the competing risk between heart failure-related events and life-threatening arrhythmias.
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Cannatà et al. (2020) studied this question.
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