Lifestyle Factors, Genetic Risk, and Cardiovascular Disease Risk among Breast Cancer Survivors: A Prospective Cohort Study in UK Biobank

Figures

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  Figure 1. Multivariable adjusted hazard ratios for CVD event risks by number of healthy lifestyle factors. CVD, cardiovascular disease; CHD, coronary heart disease; IS, ischemic stroke; HF, heart failure; CI, confidence interval. The healthy lifestyle score was divided into four groups: 0–1, 2, 3, and 4–5. The model was adjusted for age at diagnosis of breast cancer, race (white European, others), the Townsend Deprivation Index (continuous), diabetes (yes/no), hypertension (yes/no), antihypertensive drugs (yes/no), insulin treatment (yes/no), lipid treatments (yes/no), HRT (yes/no), menopause (yes/no), surgical treatment of breast cancer (yes/no). p value for trend calculated treating the genetic risk score as a continuous variable.

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  Figure 2. Subgroup analysis of healthy lifestyle score with CHD (A), IS (B), and HF (C) among females with breast cancer stratified by genetic risk. CHD, coronary heart disease; IS, ischemic stroke; HF, heart failure; CI, confidence interval. Genetic risk is classified as low risk or high risk based on median. We investigated the association of healthy lifestyle factors with CHD, IS, and HF stratified by genetic risk. The model was adjusted for age at diagnosis of breast cancer, race (white European, others), the Townsend Deprivation Index (continuous), diabetes (yes/no), hypertension (yes/no), antihypertensive drugs (yes/no), insulin treatment (yes/no), lipid treatments (yes/no), HRT (yes/no), menopause (yes/no), surgical treatment of breast cancer (yes/no), genotyping batch, and the first 10 genetic principal components.