December 2, 2024European Journal of Heart Failure11 citationsOpen Access
View Full PaperDiuretic Efficiency of a Single Dose of Subcutaneous Versus Oral Furosemide After Heart Failure Hospitalization Across Diuretic Resistance Strata: A Pilot Randomized Controlled Trial
Structured PICO
Does single-dose subcutaneous furosemide improve diuretic efficiency and peak urine sodium compared to oral furosemide in patients with diuretic resistance post-heart failure hospitalization?
P
Population
Participants with diuretic resistance (DR) discharged following recent heart failure (HF) hospitalization
I
Intervention
Single-dose subcutaneous (sc) furosemide administered via on-body infusor
C
Comparator
Oral furosemide
O
Outcome
Diuretic efficiency and peak urine sodiumsurrogate
Single-dose subcutaneous furosemide provides greater diuretic efficiency and peak urine sodium than oral furosemide in heart failure patients with diuretic resistance recently discharged from the hospital.
Abstract
AIMS: Diuretic resistance (DR) in heart failure (HF) is associated with worse outcomes. Furoscix®, a self-administered subcutaneous (sc) furosemide injection administered via on-body infusor, is approved for HF congestion relief. However, its efficacy in patients with DR post-HF hospitalization remains unknown. METHODS AND RESULTS: : treatment × diuretic resistance = 0.022). CONCLUSION: Single-dose sc furosemide was associated with greater diuretic efficiency and peak urine sodium than oral furosemide in participants with DR discharged following recent HF hospitalization.