What question did this study set out to answer?

To review the roles of AMPK and Akt/PKB signaling pathways in skeletal muscle glucose uptake and evaluate IP6K1 inhibition as a therapeutic target for insulin resistance.

February 1, 2014Diabetes Metabolic Syndrome and ObesityOpen Access

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

View Full Paper

Ask AI

Bookmark

Authors

RMRichard MackenzieUniversity Hospital Coventry BEBradley ElliottUniversity of Westminster

Discussion

Member takes

Implication

Narrative review reveals IP6K1 inhibition restores Akt/PKB signaling in type 2 diabetes, suggesting a novel therapeutic pathway for insulin resistance.

Key Points

To review the roles of AMPK and Akt/PKB signaling pathways in skeletal muscle glucose uptake and evaluate IP6K1 inhibition as a therapeutic target for insulin resistance.
Narrative synthesis of contraction-stimulated (AMPK) and insulin-stimulated (Akt/PKB) glucose transport pathways.
Biochemical evaluation of inositol hexakisphosphate kinase 1 (IP6K1) and diphosphoinositol pentakisphosphate (IP7) mechanisms modulating Akt/PKB membrane translocation.
Metformin stimulates peripheral glucose uptake through AMPK-dependent pathways, but fails to directly resolve peripheral insulin resistance.
IP7 produced by IP6K1 binds the pleckstrin homology domain of Akt/PKB, blocking its interaction with phosphatidylinositol 3,4,5-trisphosphate and preventing glucose uptake.
Targeted inhibition of IP6K1 reduces IP7 production and restores Akt/PKB translocation, representing a viable strategy to enhance insulin sensitivity.

Cite This Study

Mackenzie et al. (2014) studied this question.

synapsesocial.com/papers/6a0295e667f6ea5cc8754bc1 https://doi.org/10.2147/dmso.s48260

View Full Paper

Ask AI

Bookmark

Implication

Narrative review reveals IP6K1 inhibition restores Akt/PKB signaling in type 2 diabetes, suggesting a novel therapeutic pathway for insulin resistance.

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider