What question did this study set out to answer?

This study aims to determine if exercise induces normal AMPK activation in muscle tissue of individuals with type 2 diabetes.

May 1, 2001DiabetesOpen Access

AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial finds normal AMPK activation during exercise in type 2 diabetes, suggesting a potential treatment target.

This study aims to determine if exercise induces normal AMPK activation in muscle tissue of individuals with type 2 diabetes.
Seven subjects with type 2 diabetes and eight matched controls exercised for 45 min at 70% maximum workload.
Muscle biopsies were taken at various time points to measure AMPK activity.
Blood glucose levels were monitored before and after exercise.
Blood glucose decreased from 7.6 to 4.77 mmol/l in the diabetic group after 45 min of exercise.
AMPK alpha2 activity increased 2.7-fold over basal at 20 min in both groups, remaining elevated.
No significant changes were observed in AMPK alpha1 activity or isoform expression between groups.

Musi et al. (2001) studied this question.

View Full Paper

Ask AI

Bookmark