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This research investigates the relationships between longitudinal relaxation rates and regional concentrations of iron and water in the human brain.

January 1, 2001Magnetic Resonance in MedicineOpen Access

Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

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This research investigates the relationships between longitudinal relaxation rates and regional concentrations of iron and water in the human brain.
Data collected from 12 healthy adults using the TOMROP sequence to acquire R(1) maps at 3 T.
Mean longitudinal relaxation rates (R(1)) measured across various brain regions such as the prefrontal cortex and thalamus.
Correlation analyses performed to link R(1) values with estimated iron and water concentrations.
R(1) values strongly correlate with estimated nonheme iron concentrations in gray matter (r = 0.984, P < 0.0001).
R(1) values correlate well with water content estimates, showing a better prediction when including white matter (r = 0.976, P < 0.0001).
The variation of R(1) across gray matter regions is primarily explained by differences in water content.

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Implication

Randomized trial examines correlations between relaxation rates, iron, and water contents in the human brain, indicating significant interregional differences.

Cite This Study

Gelman et al. (2001) studied this question.

synapsesocial.com/papers/6a02fa4fd2181737fb9e291e https://doi.org/10.1002/1522-2594(200101)45:1<71::aid-mrm1011>3.0.co;2-2

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Implication

Randomized trial examines correlations between relaxation rates, iron, and water contents in the human brain, indicating significant interregional differences.

Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

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Discussion

Implication

Cite This Study

Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: Relation to estimated iron and water contents

Key Points

Discussion

Implication

Cite This Study

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