What question did this study set out to answer?

To review the mechanisms governing tumor suppressor microRNA deregulation within cancer cells and the tumor microenvironment, as well as their clinical implications for cancer diagnosis, prognosis, and treatment.

October 15, 2021Frontiers in OncologyOpen Access

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

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Authors

KOKhalid OtmaniUniversité Libre de Bruxelles PLPhilippe LewalleNational Institutes of Health

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Implication

Review details mechanisms of tumor suppressor microRNA deregulation in cancer cells and surrounding microenvironments, highlighting therapeutic potential of synthetic microRNA replacement.

Key Points

To review the mechanisms governing tumor suppressor microRNA deregulation within cancer cells and the tumor microenvironment, as well as their clinical implications for cancer diagnosis, prognosis, and treatment.
Synthesized molecular evidence detailing transcriptional and posttranscriptional control mechanisms of mature microRNA expression.
Evaluated preclinical and profiling literature regarding microRNA deregulation within cancer cells and the surrounding tumor microenvironment.
Downregulation of tumor suppressor microRNAs elevates the translation of oncogenes, driving tumor cell aggressiveness and accelerating malignant progression.
Dysregulated microRNA signaling alters communication within the tumor microenvironment to support tumor growth and immune evasion.
Re-introducing depleted tumor suppressors via synthetic microRNA mimics shows promise as a targeted therapeutic approach alongside noninvasive biomarker applications.

Cite This Study

Otmani et al. (2021) studied this question.

synapsesocial.com/papers/6a0333dd67f6ea5cc87588cf https://doi.org/10.3389/fonc.2021.708765

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Implication

Review details mechanisms of tumor suppressor microRNA deregulation in cancer cells and surrounding microenvironments, highlighting therapeutic potential of synthetic microRNA replacement.

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

Tumor Suppressor miRNA in Cancer Cells and the Tumor Microenvironment: Mechanism of Deregulation and Clinical Implications

Discussion

Member takes

Implication

Key Points

Cite This Study

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