April 2, 2011Journal of Pineal Research

Intracoronary melatonin increases coronary blood flow and cardiac function through β-adrenoreceptors, MT1/MT2 receptors, and nitric oxide in anesthetized pigs

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Why the study?

Does intracoronary melatonin improve coronary blood flow and cardiac function in anesthetized pigs?

Population

Anesthetized pigs (n=75 total across multiple experimental groups)

Comparison

Intracoronary melatonin infused at 70 pg per… vs Baseline/control values and various receptor…

Design

Preclinical

Authors

EGElena GrossiniHeart Failure / Cardiomyopathy CMClaudio MolinariUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”FUFrancesca UbertiUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”

Discussion

Member takes

Implication

Melatonin effects in pigs remain hypothesis-generating; clinical translation unproven and should not guide practice.

Structured PICO

Does intracoronary melatonin improve coronary blood flow and cardiac function in anesthetized pigs?

Population

Anesthetized pigs (n=75 total across multiple experimental groups)

Intervention

Intracoronary melatonin infused at 70 pg per mL/min of coronary blood flow

Comparator

Baseline/control values and various receptor blockades (muscarinic, α-adrenoreceptors, β1/β2-adrenoreceptors, NO synthase, MT1/MT2 inhibitors)

Outcome

Coronary blood flow, cardiac function (dP/dt(max), segmental shortening, cardiac output), and coronary NO releasesurrogate

Intracoronary melatonin increases coronary blood flow and cardiac function in pigs through mechanisms involving MT1/MT2 receptors, β-adrenoreceptors, and nitric oxide.

Cite This Study

Grossini et al. (2011) studied this question.

synapsesocial.com/papers/6a033cfda7089d6435654170 https://doi.org/10.1111/j.1600-079x.2011.00886.x

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Intracoronary melatonin increases coronary blood flow and cardiac function through β-adrenoreceptors, MT1/MT2 receptors, and nitric oxide in anesthetized pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracoronary melatonin increases coronary blood flow and cardiac function through β-adrenoreceptors, MT1/MT2 receptors, and nitric oxide in anesthetized pigs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider