Characterization of melatonin receptors and signal transduction system in rat arteries forming the circle of Willis

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Structured PICO

Population

Rat brain arteries forming the circle of Willis

Intervention

In vitro autoradiography with [125I]iodomelatonin, coincubation with guanosine-5'-O-(3-thiotriphosphate), and melatonin with/without pertussis toxin

Outcome

Characterization of melatonin receptors and signal transduction systemsurrogate

Melatonin receptors in rat cerebral arteries are linked to their second messenger through a pertussis toxin-sensitive G-protein.

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Melatonin receptors couple via PTX-sensitive G-proteins in rat cerebral arteries; leaves open relevance to human cerebrovascular regulation.

Simona Capsoni (1994) studied this question.

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Melatonin receptors couple via PTX-sensitive G-proteins in rat cerebral arteries; leaves open relevance to human cerebrovascular regulation.