Why the study?
Does melatonin potentiate phenylephrine-stimulated intracellular Ca2+ transients in smooth muscle cells of large arteries of chick embryos?
Does melatonin potentiate phenylephrine-stimulated intracellular Ca2+ transients in smooth muscle cells of large arteries of chick embryos?
Melatonin receptors are present in the smooth muscle of large arteries in chick embryos and potentiate alpha1-adrenergic stimulation of intracellular calcium.
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May indicate melatonin-alpha1 synergy in embryonic vessels; leaves open any relevance to human vascular function or therapy.
Wang et al. (2002) studied this question.
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