Key result
Melatonin produced direct vasoconstriction and concentration-dependent potentiation of electrically-evoked isometric contractions in the rat isolated tail artery, suggesting a MEL1-like receptor subtype.
Population
Isolated tail artery segments from juvenile Wistar rats
Design
Preclinical
Authors
Loading...
May guide preclinical vascular melatonin studies; leaves open translation to human cardiovascular effects.
The rat isolated tail artery using a wire myograph provides a reproducible model for assessing vascular melatonin receptors, which exhibit a MEL1-like pharmacological profile.
Ting et al. (1997) studied this question. Melatonin and putative melatonin receptor ligands was evaluated on Vasoconstriction (reduction in lumen diameter) and enhancement of electrically-evoked isometric contractions. Melatonin produced direct vasoconstriction and concentration-dependent potentiation of electrically-evoked isometric contractions in the rat isolated tail artery, suggesting a MEL1-like receptor subtype.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: