Key result
Melatonin (0.1 µM) significantly restored the spontaneously diminished electrical field stimulation-evoked contraction of juvenile rat tail artery segments, increasing contraction force by up to 48.4%.
Why the study?
Does melatonin restore diminished neurogenic reactivity in juvenile rat tail artery segments?
Does melatonin restore diminished neurogenic reactivity in juvenile rat tail artery segments?
Melatonin restores diminished neurogenic reactivity in juvenile rat tail arteries, likely by potentiating the contractile response rather than altering postjunctional membrane sensitivity to noradrenaline.
Melatonin may modulate juvenile vascular reactivity in rat models; leaves open translation to human neurogenic control and precludes clinical inference.
The effect of melatonin on neurogenic reactivity of the juvenile rat tail artery segment was studied. The electrical field stimulation-evoked contraction of the segment decreased in the course of the experiment. Melatonin (0.1 microM) applied at different time points of the experiment produced an increase in the contraction, which directly correlated with a spontaneous decrease in the electrical field stimulation-evoked response. The increase in the potentiating effect of melatonin in the course of the experiment was not due to sensitization of the segment to this substance. Noradrenaline-evoked contraction of the vessel segment was not changed by melatonin. The data indicate that melatonin restores the diminished neurogenic reactivity of the juvenile rat tail artery probably by potentiation of the contractile response of the vessel, but this effect is hardly due to a change in sensitivity of the postjunctional membrane to noradrenaline.
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Karachentseva et al. (2004) studied Diminished neurogenic reactivity of the tail artery (n=48). Melatonin vs. Control (Krebs solution with ethanol / baseline prior to administration) was evaluated on Electrical field stimulation (EFS)-evoked contraction of the tail artery segment (p=<0.05). Melatonin (0.1 µM) significantly restored the spontaneously diminished electrical field stimulation-evoked contraction of juvenile rat tail artery segments, increasing contraction force by up to 48.4%.
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