Population
Type 2 diabetic mice induced by a high-fat diet combined with a single injection of low-dose streptozotocin
Comparison
mitoTempol (a mitochondria-specific O2 scavenger) vs Control mice and untreated T2D mice
Design
Preclinical
Authors
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MitoTempol restores coronary endothelial function in T2D mice; leaves open translation of mitochondrial ROS scavenging to human therapy.
Augmented SOD2 ubiquitination increases mitochondrial ROS in coronary endothelial cells, attenuating coronary vascular relaxation in T2D mice, which can be restored by mitochondria-specific ROS scavengers.
Cho et al. (2013) studied this question.