Functionally uni-leaflet mitral valves can occur in a familial pattern and be compatible with asymptomatic adult life with minimal regurgitation.
Supports awareness of possible familial uni-leaflet mitral valves; leaves open questions on prevalence, genetics, and outcomes.
Functionally uni-leaflet mitral valves are extremely rare. In severe cases, they are considered incompatible with life beyond the neonatal period. We present a case series of three adults with almost complete absence of the posterior mitral valve leaflet and who are asymptomatic, with no more than mild mitral regurgitation. We believe that this is the first reported instance of such findings in a single family.
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Kanagala et al. (2010) studied this question.
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