Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China

Figures

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  Fig. 1. Flow chart of the study population enrollment. NSTE-ACS non-ST-segment elevation acute coronary syndrome, PCI percutaneous coronary intervention, FBG fasting blood glucose, HbA1c glycosylated hemoglobin A1c, T1DM type 1 diabetes mellitus, CABG coronary artery bypass grafting, TGs triglycerides, eGFR estimated glomerular filtration rate, ALT alanine transaminase, AST aspartate transaminase, BMI body mass index, TyG triglyceride glucose

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  Fig. 2. Kaplan–Meier curves for endpoint events according to the optimal cutoff point of TyG index. a Kaplan–Meier curves for primary endpoint; b Kaplan–Meier curves for all-cause death; c Kaplan–Meier curves for non-fatal MI; d Kaplan-Meier curves for ischemia-driven revascularization. The groups were stratified by the optimal cutoff point of TyG index determined by ROC curve analysis. TyG triglyceride glucose, MI myocardial infarction, PCI percutaneous coronary intervention, HR hazard ratio, CI confidence interval

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  Fig. 3. Cox proportional hazards analysis evaluating prognostic implication of TyG index in various stratifications. HR was evaluated by 1-unit increase of TyG index. BMI body mass index, UA unstable angina, NSTEMI non-ST-segment elevation myocardial infarction, HbA1c glycosylated hemoglobin A1c, LDL-C low-density lipoprotein cholesterol, HR hazard ratio, CI confidence interval

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  Fig. 4. C-statistics evaluating incremental effect of FBG, HbA1c, TGs or TyG index beyond baseline risk model. a Baseline risk model vs. +FBG; b baseline risk model vs. +HbA1c; c baseline risk model vs. +TGs; d baseline risk model vs. +TyG index. The baseline risk model includes age, sex (female), smoking, SBP, prior MI, prior PCI, TC, HDL-C, eGFR, LVEF, SYNTAX score, LM treatment, complete revascularization, number of stents and statins at discharge. FBG fasting blood glucose, HbA1c glycosylated hemoglobin A1c, TGs triglycerides, TyG triglyceride glucose, AUC area under the curve