August 23, 2012Biofabrication

Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds

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Population

Porcine aortic valve interstitial cells seeded on 3D printed poly-ethylene glycol-diacrylate hydrogels…

Design

Preclinical

Follow-up

up to 21 days

Authors

LHLaura A. HockadayTufts University KKKevin H. KangBoston University NCN W ColangeloCornell University

Discussion

Member takes

Implication

Supports biofabrication of aortic valve scaffolds; hypothesis-generating and leaves open in vivo durability plus clinical translation.

Structured PICO

Population

Porcine aortic valve interstitial cells (PAVIC) seeded on 3D printed poly-ethylene glycol-diacrylate (PEG-DA) hydrogels (700 or 8000 MW) supplemented with alginate

Intervention

Simultaneous 3D printing/photocrosslinking technique for engineering complex, heterogeneous aortic valve scaffolds

Outcome

Geometric accuracy (shape fidelity), elastic modulus, printing time, and cell viabilitysurrogate

A novel 3D printing and photocrosslinking technique can rapidly fabricate anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds that support high cell viability.

Cite This Study

Hockaday et al. (2012) studied this question.

synapsesocial.com/papers/6a0367a3ffb63c178681e901 https://doi.org/10.1088/1758-5082/4/3/035005

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Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid 3D printing of anatomically accurate and mechanically heterogeneous aortic valve hydrogel scaffolds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider