Report of two pregnant cases with disseminated peritoneal leiomyomatosis

Leiomyomatosis peritonealis disseminata (LPD) is very occasional disorder noted by formation of numerous nodules which spread across the peritoneal and omental surfaces. It is a benign disease of unknown etiology and usually occurs in women of childbearing age. This case study report included two cases attended Dar EL -Shefa hospital in a period from 2016 to 2020 .The first one is a 29 years-old female was hospitalized for an elective cesarean section. A large omental mass and multiple small nodules in the ovary and intestine were observed incidentally after fetal delivery and expulsion of the uterus that was initially considered as leiomyosarcoma. The histopathology and immune-histochemistry of the masses were consistent with the diagnosis of DPL. The second case is a case of a 31-years-old female, 30 weeks of pregnancy was hospitalized with acute abdominal symptoms and elevated inflammatory serum markers. An exploratory laparotomy was performed at 30 weeks of gestation while removing all visible tumors. In subsequent pregnancy there is evidence of recurrent LPD lesions with no symptoms. Strict follow up, prior time of delivery, the patient was admitted to hospital, both the patient and the fetus were in good condition. After delivery, A hystero-salpingo-oophorectomy was performed. The main objective of this case presentations is to clarify the role of immunohistochemistry in the diagnosis of LPD and to differentiate it from other mimic malignant peritoneal tumors as well as simplify the clinical data regarding delivery and follow-up information for patients with LPD who developed during pregnancy