Why the study?
Ideal energy application modes for bipolar radiofrequency ablation to treat ventricular arrhythmias originating deep in thick myocardium have not been well established.
Does impedance-decline-guide power control bipolar ablation improve the creation of transmural lesions without steam-pop compared to fixed power ablation in thick porcine ventricles?
Does impedance-decline-guide power control bipolar ablation improve the creation of transmural lesions without steam-pop compared to fixed power ablation in thick porcine ventricles?
Impedance-decline-guided power control during bipolar radiofrequency ablation safely creates transmural lesions in thick ventricular myocardium without steam-pops in a preclinical model.
Impedance-guided bipolar ablation merits human translation studies; leaves open safety/efficacy in clinical ventricular substrates.
INTRODUCTION: Bipolar (BIP) radiofrequency (RF) ablation creates deep myocardial lesions but ideal energy application modes to treat ventricular arrhythmias originating from deep inside the thick myocardium have not been well established. An experimental study was performed to clarify whether high power and long application time BIP ablation were performable by impedance-decline-guide power control (PC) and whether it could create transmural lesions in the thick ventricle with a minimum risk of steam-pop. METHODS AND RESULTS: Perfused porcine ventricle (18.4 ± 2.3 mm) was placed in an experimental bath and BIP ablation (50 W) for 120 s was attempted with catheter contact of 30-g using two protocols; fixed power (FP) and impedance-decline-guide PC. In the latter protocol, BIP ablation was started from 50 W, while the energy was decreased to 40-20 W according to the impedance decline during RF ablation. FP ablation was attempted in 30 applications and the transmural lesion was created in all 30, although steam-pop occurred in 16/30 applications (53%). Low minimum impedance, large total impedance decline (TID), and %-TID were associated with the steam-pop occurrence. PC ablation was attempted in another 21 applications, and the transmural lesion was created in all 21 without steam-pop. PC ablation was superior to FP ablation (21/21 vs. 14/30, p < .001) in the creation of a transmural lesion without resulting in steam-pop. CONCLUSIONS: High power and long application time BIP ablation seems to be feasible according to the impedance-decline-guide approach, which could create transmural lesions in thick porcine ventricles with minimal risk of steam-pop.
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Saitoh et al. (2022) studied this question.
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