August 5, 1997Circulation

ACE Inhibition

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Why the study?

Does local brachial artery infusion of perindoprilat attenuate sympathetic vasoconstriction in healthy normotensive men?

Population

8 healthy, normotensive male volunteers, aged 20 to 32 years.

Comparison

Local brachial artery infusion of perindoprilat… vs Local brachial artery infusion of placebo…

Authors

DLDeclan LyonsIRCCS San Camillo Hospital SRSuzanne RoyChinook Regional Hospital SOSharon O’ByrneTakeda (Switzerland)

Discussion

Member takes

Implication

Supports sympatholytic ACE inhibitor action in healthy men; hypothesis-generating for clinical relevance in cardiovascular disease.

Structured PICO

Does local brachial artery infusion of perindoprilat attenuate sympathetic vasoconstriction in healthy normotensive men?

Population

8 healthy, normotensive male volunteers, aged 20 to 32 years.

Intervention

Local brachial artery infusion of perindoprilat (5 nmol/mL) coinfused during lower body negative pressure and norepinephrine administration.

Comparator

Local brachial artery infusion of placebo (0.9% NaCl) coinfused during lower body negative pressure and norepinephrine administration.

Outcome

Forearm blood flow (FABF) responses to lower body negative pressure (LBNP) and increasing increments of norepinephrine.surrogate

Local infusion of perindoprilat attenuates sympathetic vasoconstriction in healthy men, suggesting a postsynaptic sympatholytic mechanism contributes to the clinical benefits of ACE inhibitors.

Cite This Study

Lyons et al. (1997) studied this question.

synapsesocial.com/papers/6a03bfe1d2c35e4200e96af9 https://doi.org/10.1161/01.cir.96.3.911

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ACE Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ACE Inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider