Why the study?
Does benazepril attenuate sympathetic vasoconstriction in untreated mild essential hypertensives?
Population
8 untreated mild essential hypertensives on a moderately low-sodium diet (50 mmol/l per day)
Comparison
Benazepril 10 mg oral vs Placebo
Design
RCT, randomized crossover, double-blind
Authors
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Benazepril attenuates sympathetic vasoconstriction in mild hypertension; confirms ACE inhibitor class effect on sympathomodulation.
Does benazepril attenuate sympathetic vasoconstriction in untreated mild essential hypertensives?
Benazepril attenuates sympathetic vasoconstriction in essential hypertension, suggesting this sympathomoderating effect is a class feature of ACE inhibitors.
Giannattasio et al. (1992) studied this question.
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