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January 1, 1989Journal of Hypertension

Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patients

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Why the study?

Does benazepril alter the plasma atrial natriuretic factor (ANF) response to volume expansion in patients with essential hypertension?

Population

10 patients with essential hypertension

Comparison

Benazepril 10 mg orally once a day for 2 days… vs Placebo for 2 days with volume expansion

Design

RCT, randomly allocated, double-blind

Follow-up

4 weeks

Authors

PDPaolo Dessı̀-FulgheriMarche Polytechnic UniversityMMM MotoleseUniversità Cattolica del Sacro CuoreGNG. Di NotoOspedale San Carlo

Discussion

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Implication

Supports benazepril improving cardiac compliance in hypertension; extends ACEI effects on ANF dynamics to volume challenge.

Structured PICO

Does benazepril alter the plasma atrial natriuretic factor (ANF) response to volume expansion in patients with essential hypertension?

P
Population
10 patients with essential hypertension
I
Intervention
Benazepril 10 mg orally once a day for 2 days (acute phase) followed by 4 weeks (chronic phase), with volume expansion induced by infusing 1 litre saline in 30 min
C
Comparator
Placebo for 2 days (crossover design) with volume expansion
O
Outcome
Plasma atrial natriuretic factor (ANF) levels in response to acute volume expansionsurrogate

Benazepril blunts and delays the atrial natriuretic factor response to volume expansion in hypertensive patients, likely reflecting improved cardiac performance or compliance due to blood pressure reduction.

Cite This Study

Dessı̀-Fulgheri et al. (1989) studied this question.

synapsesocial.com/papers/6a840f1cc967ec513cbd84e7https://doi.org/10.1097/00004872-198900076-00146

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial Natriuretic Factor Response to Acute Volume Expansion in Borderline Hypertension. Role of Ace-Inhibition and Changes in Peripheral Venous Tone1993 · 4 citations
  2. 2Atrial natriuretic factor in hypertension: bioactivity at normal plasma levels.1989 · 24 citations
  3. 3Effect of Salt Balance on the Renal and Hemodynamic Actions of Benazepril in Normal Men1989 · 11 citations
  4. 4Low-dose infusion of atrial natriuretic factor in mild essential hypertension.1989 · 45 citations
  5. 5Effects of incremental infusions of atrial natriuretic factor on aldosterone, renin, and blood pressure in humans.1988 · 47 citations