March 1, 1989Clinical Pharmacology & Therapeutics

A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acting angiotensin-converting enzyme inhibitor, in patients with chronic congestive heart failure

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Why the study?

Does benazepril hydrochloride improve acute hemodynamics in patients with chronic congestive heart failure?

Population

26 patients with New York Heart Association class III or IV congestive heart failure and left ventricular…

Comparison

Benazepril hydrochloride 2 or 5 mg single oral… vs Baseline (control)

Design

Cohort

Follow-up

24 hours

Authors

JIJerald InselMedStar Good Samaritan Hospital DMDavid M. MirvisUniversity of Tennessee Health Science Center MBMichael J. BolandNeuroDevelopment Center

Discussion

Member takes

Implication

May support acute hemodynamic effects of benazepril in severe chronic HF; leaves open outcome confirmation in randomized trials.

Structured PICO

Does benazepril hydrochloride improve acute hemodynamics in patients with chronic congestive heart failure?

Population

26 patients with New York Heart Association class III or IV congestive heart failure and left ventricular ejection fractions <35%, cardiac indexes <2.1 L/min/m2, and pulmonary artery wedge pressures >12 mm Hg

Intervention

Benazepril hydrochloride 2 or 5 mg single oral dose

Comparator

Baseline (control)

Outcome

Acute hemodynamic effects (cardiac output, heart rate, systemic and pulmonary vascular resistances, mean pulmonary and systemic arterial pressures, and pulmonary artery wedge pressure)surrogate

A single oral dose of benazepril hydrochloride produces significant and sustained hemodynamic improvements for up to 24 hours in patients with severe chronic heart failure.

Cite This Study

Insel et al. (1989) studied this question.

synapsesocial.com/papers/6a9111dab43632dc563e7778 https://doi.org/10.1038/clpt.1989.34

Topics

Heart failure HFrEF treatment

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A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acting angiotensin-converting enzyme inhibitor, in patients with chronic congestive heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

A multicenter study of the safety and efficacy of benazepril hydrochloride, a long-acting angiotensin-converting enzyme inhibitor, in patients with chronic congestive heart failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider