Key result
Once-daily benazepril hydrochloride (5 to 40 mg) resulted in clinically important reductions in diastolic and systolic blood pressures lasting 12 to 24 hours post-dose over 28 days of treatment.
Why the study?
Does once-daily oral benazepril hydrochloride reduce blood pressure in patients with mild-to-moderate hypertension?
Population
Patients with mild-to-moderate hypertension and diastolic blood pressure between 95 and 114 mm Hg.
Comparison
Benazepril hydrochloride 5, 10, 20, or 40 mg… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
28 days
Authors
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Supports once-daily benazepril for 24-hour BP control in mild-to-moderate hypertension; confirms sustained ACEI efficacy in RCTs.
RCT
Double-blind
randomized
Does once-daily oral benazepril hydrochloride reduce blood pressure in patients with mild-to-moderate hypertension?
Once-daily benazepril hydrochloride provides sustained blood pressure reduction over 24 hours in patients with mild-to-moderate hypertension.
Weinberger et al. (1990) conducted an RCT in mild-to-moderate hypertension. benazepril hydrochloride vs. placebo was evaluated on diastolic and systolic blood pressures. Once-daily benazepril hydrochloride (5 to 40 mg) resulted in clinically important reductions in diastolic and systolic blood pressures lasting 12 to 24 hours post-dose over 28 days of treatment.
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