What question did this study set out to answer?

To evaluate the efficacy and tolerability of benazepril combined with amlodipine compared to benazepril monotherapy in patients with hypertension inadequately controlled by an ACE inhibitor alone.

October 1, 1997Journal of Cardiovascular Pharmacology

Combined Therapy with Benazepril and Amlodipine in the Treatment of Hypertension Inadequately Controlled by an ACE Inhibitor Alone

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Why the study?

Does the combination of benazepril and amlodipine improve blood pressure control in patients with hypertension inadequately controlled by benazepril alone?

Population

448 patients, aged 24-73 years, with hypertension inadequately controlled with ACE-inhibitor monotherapy.

Comparison

Benazepril 10 mg plus amlodipine 2.5 mg or 5 mg… vs Benazepril 10 mg plus placebo once daily for 8…

Design

RCT, randomized, double-blind, placebo-controlled

Follow-up

8 weeks

Authors

RFRoberto FogariGeneral / Preventive / Lipids LCL CoreaUniversity of Perugia OCOndina CardoniON Semiconductor (United States)

Discussion

Member takes

Implication

Supports adding amlodipine to benazepril in inadequately controlled hypertension; confirms additive efficacy of this combination in an RCT.

Key Points

To evaluate the efficacy and tolerability of benazepril combined with amlodipine compared to benazepril monotherapy in patients with hypertension inadequately controlled by an ACE inhibitor alone.
Multicenter, randomized, double-blind, placebo-controlled trial involving 448 patients (mean age 55 years) with sitting DBP between 95 and 120 mm Hg after a 2-week placebo and 4-week single-blind benazepril (10 mg daily) run-in.
Patients were randomized to receive benazepril 10 mg plus placebo, benazepril 10 mg plus amlodipine 2.5 mg, or benazepril 10 mg plus amlodipine 5 mg once daily for 8 weeks.
Sitting and standing blood pressure, heart rate, and body weight were assessed 22 to 26 hours post-dose at baseline, week 4, and week 8.
Both combination regimens achieved significantly lower 24-hour post-dose sitting and standing systolic and diastolic blood pressure compared to benazepril monotherapy.
Treatment success rates were 69.2% in the benazepril 10 mg/amlodipine 2.5 mg group and 65.8% in the benazepril 10 mg/amlodipine 5 mg group, compared to 40.5% with benazepril monotherapy.
Tolerability was favorable across all three groups with no significant laboratory abnormalities, and no significant differences in efficacy or safety were observed between the two amlodipine doses.

Structured PICO

Does the combination of benazepril and amlodipine improve blood pressure control in patients with hypertension inadequately controlled by benazepril alone?

Population

448 patients (213 men, 235 women), aged 24-73 years (mean 55 years), with hypertension inadequately controlled with ACE-inhibitor monotherapy (mean DBP ≥95 and ≤120 mm Hg after 4-week benazepril 10 mg run-in).

Intervention

Benazepril 10 mg plus amlodipine 2.5 mg or 5 mg once daily for 8 weeks.

Comparator

Benazepril 10 mg plus placebo once daily for 8 weeks.

Outcome

24-h postdosing sitting and standing systolic BP (SBP) and DBP values, and success rate at 8 weeks.surrogate

The addition of amlodipine (2.5 or 5 mg) to benazepril (10 mg) significantly improves blood pressure control in patients with hypertension inadequately controlled by benazepril monotherapy.

Cite This Study

Fogari et al. (1997) studied this question.

synapsesocial.com/papers/6a74cfbfd93df8ecca0922e9 https://doi.org/10.1097/00005344-199710000-00014

Topics

Hypertension management

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Implication

Supports adding amlodipine to benazepril in inadequately controlled hypertension; confirms additive efficacy of this combination in an RCT.

Combined Therapy with Benazepril and Amlodipine in the Treatment of Hypertension Inadequately Controlled by an ACE Inhibitor Alone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Combined Therapy with Benazepril and Amlodipine in the Treatment of Hypertension Inadequately Controlled by an ACE Inhibitor Alone

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider