Why the study?
Does amlodipine/benazepril combination therapy improve arterial stiffness and left ventricular hypertrophy more effectively than component monotherapy in patients with mild to moderate hypertension?
Population
106 patients with mild-to-moderate hypertension
Comparison
Amlodipine/benazepril 5/20 mg combination… vs Amlodipine 10 mg monotherapy or benazepril 40 mg…
Design
RCT, randomized, parallel group, open label, blinded endpoint
Follow-up
26 weeks
Authors
Loading...
Favors low-dose amlodipine/benazepril over higher-dose monotherapies for arterial stiffness in hypertension; extends evidence beyond equivalent BP reduction.
Does amlodipine/benazepril combination therapy improve arterial stiffness and left ventricular hypertrophy more effectively than component monotherapy in patients with mild to moderate hypertension?
Low-dose amlodipine/benazepril combination therapy provides greater improvements in arterial stiffness and left ventricular hypertrophy than higher-dose component monotherapies, despite similar blood pressure reductions.
J NEUTEL (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: