Why the study?
Does the combination of amlodipine 2.5 mg and benazepril 10 mg daily improve blood pressure reduction compared to monotherapy or placebo in patients with mild to moderate systemic hypertension?
Population
401 patients with mild to moderate (stages I and II) systemic hypertension
Comparison
Combination of amlodipine 2.5 mg and benazepril… vs Amlodipine 2.5 mg daily monotherapy, benazepril…
Design
RCT, randomized, parallel-group, single-blind run-in, double-blind
Authors
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Supports low-dose combination as initial therapy for mild-moderate hypertension; confirms additive BP reduction over monotherapies in RCTs.
Does the combination of amlodipine 2.5 mg and benazepril 10 mg daily improve blood pressure reduction compared to monotherapy or placebo in patients with mild to moderate systemic hypertension?
Low-dose combination therapy with amlodipine and benazepril offers superior blood pressure lowering efficacy and less edema compared to amlodipine monotherapy.
Frishman et al. (1995) studied this question.
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