Key result
Amlodipine/benazepril 10/40 and 10/20 mg/day reduced sitting BP by 13.3/12.7 and 12.1/11.6 mmHg, respectively, compared with 6.6/8.5 mmHg for amlodipine monotherapy (p<0.0001).
Why the study?
Does amlodipine/benazepril combination therapy improve blood pressure reduction in patients not adequately controlled with amlodipine monotherapy?
Population
812 patients whose blood pressure was not adequately controlled with amlodipine monotherapy
Comparison
Amlodipine/benazepril combination therapy vs Amlodipine monotherapy 10 mg/day
Design
RCT, Randomized to one of three treatment groups
Authors
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Favors amlodipine/benazepril over monotherapy for greater BP reduction; extends evidence for dual therapy in amlodipine-uncontrolled hypertension.
RCT (n=812)
randomized
Does amlodipine/benazepril combination therapy improve blood pressure reduction in patients not adequately controlled with amlodipine monotherapy?
p-value: p=< 0.0001
Amlodipine/benazepril combination therapy provides superior blood pressure reduction and higher responder rates compared to amlodipine monotherapy in patients with inadequately controlled hypertension.
Chrysant et al. (2007) conducted an RCT in blood pressure not adequately controlled with amlodipine monotherapy (n=812). amlodipine/benazepril vs. amlodipine 10 mg/day was evaluated on decrease of mean sitting systolic and mean sitting diastolic BP (p=< 0.0001). Amlodipine/benazepril 10/40 and 10/20 mg/day reduced sitting BP by 13.3/12.7 and 12.1/11.6 mmHg, respectively, compared with 6.6/8.5 mmHg for amlodipine monotherapy (p<0.0001).
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