Why the study?
Does amlodipine/benazepril combination therapy improve endothelial function and blood pressure compared to amlodipine monotherapy in hypertensive subjects with endothelial dysfunction risk factors?
Population
70 hypertensive subjects with at least one other endothelial dysfunction risk factor
Comparison
Amlodipine/benazepril combination for 12 weeks vs Amlodipine monotherapy for 12 weeks
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Combination yielded no significant FMD advantage over monotherapy despite greater BP reduction; leaves open additive endothelial benefit in larger trials.
Does amlodipine/benazepril combination therapy improve endothelial function and blood pressure compared to amlodipine monotherapy in hypertensive subjects with endothelial dysfunction risk factors?
Amlodipine/benazepril combination therapy provides superior blood pressure reduction compared to amlodipine monotherapy, although it does not significantly improve endothelial function beyond the effects of monotherapy.
Mohler et al. (2006) studied this question.
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