What does this research mean for the field?

Benazepril monotherapy effectively controls blood pressure without causing adverse renal hemodynamic effects in hypertensive patients with moderately impaired renal function. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the blood pressure, hormonal, and renal hemodynamic effects of the ACE inhibitor benazepril in hypertensive patients with moderate renal insufficiency.

July 1, 1989The Journal of Clinical Pharmacology

Effect of Benazepril Monotherapy in Subjects with Hypertension Associated with Renal Dysfunction

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Why the study?

Does benazepril monotherapy effectively control blood pressure without adverse renal hemodynamic effects in hypertensive patients with mild to moderate renal dysfunction?

Population

9 hypertensive patients with mild to moderate renal dysfunction (mean creatinine clearance 56 ml/min/1.73 m2)

Design

Case_series

Follow-up

12 weeks

Authors

GRGarry P. ReamsUniversity of Missouri ALAlisa LauUniversity of Missouri JBJohn H. BauerUniversity of Minnesota System

Discussion

Member takes

Implication

May support benazepril in select renal impairment cases; leaves open need for controlled trials.

Key Points

To assess the blood pressure, hormonal, and renal hemodynamic effects of the ACE inhibitor benazepril in hypertensive patients with moderate renal insufficiency.
Prospective interventional trial in N=9 hypertensive patients with mild to moderate renal dysfunction (mean baseline creatinine clearance 56 ml/min/1.73 m²).
Administered benazepril (2 to 20 mg twice daily) as monotherapy over a 12-week treatment duration.
Assessed blood pressure, plasma renin activity, plasma aldosterone, 24-hour urinary protein, and clearance rates of creatinine, Tc99m-DTPA, and para-amino-hippurate before and after treatment.
Blood pressure was well controlled throughout treatment, accompanied by stimulation of plasma renin activity and suppression of plasma aldosterone.
Mean serum potassium increased from 3.9 to 4.2 mEq/L following 12 weeks of benazepril monotherapy.
Benazepril caused no adverse renal hemodynamic effects, maintaining stable glomerular filtration and clearance parameters.

Structured PICO

Does benazepril monotherapy effectively control blood pressure without adverse renal hemodynamic effects in hypertensive patients with mild to moderate renal dysfunction?

Population

9 hypertensive patients with mild to moderate renal dysfunction (mean creatinine clearance 56 ml/min/1.73 m2)

Intervention

Benazepril (2 to 20 mg twice daily) monotherapy for 12 weeks

Outcome

Blood pressure, humoral and renal effects (plasma renin activity, plasma aldosterone, clearances of creatinine, TC99m-DTPA, para-amino-hippurate, and 24-hour urinary excretion of protein)surrogate

Benazepril monotherapy effectively controls blood pressure without adverse renal hemodynamic effects in hypertensive patients with moderate renal insufficiency.

Cite This Study

Reams et al. (1989) studied this question.

synapsesocial.com/papers/6a19cd70a2165c1276df0d3a https://doi.org/10.1002/j.1552-4604.1989.tb03389.x

Topics

Hypertension management

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Effect of Benazepril Monotherapy in Subjects with Hypertension Associated with Renal Dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of Benazepril Monotherapy in Subjects with Hypertension Associated with Renal Dysfunction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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