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January 1, 1993Clinical and Experimental Hypertension

Atrial Natriuretic Factor Response to Acute Volume Expansion in Borderline Hypertension. Role of Ace-Inhibition and Changes in Peripheral Venous Tone

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Why the study?

Does captopril alter the ANF response to acute volume expansion in patients with borderline hypertension?

Population

16 subjects with borderline hypertension

Comparison

Short-term administration of captopril followed… vs Short-term administration of placebo followed by…

Design

Other

Follow-up

2 hours

Authors

CBClaudio BorghiPreventive CardiologySBStefano BoschiFCFrancesco CostaBocconi University

Discussion

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Implication

May blunt early ANF response to volume expansion in borderline hypertension; leaves open contribution to pressor derangements.

Structured PICO

Does captopril alter the ANF response to acute volume expansion in patients with borderline hypertension?

P
Population
16 subjects with borderline hypertension
I
Intervention
Short-term administration of captopril followed by a two-hour isotonic i.v. NaCl infusion
C
Comparator
Short-term administration of placebo followed by a two-hour isotonic i.v. NaCl infusion
O
Outcome
Neuro-humoral and hemodynamic response (ANF release, venous distensibility, blood pressure) to volume expansionsurrogate

ACE-inhibition delays the ANF response to saline infusion in borderline hypertensives, which may contribute to pressor and neuro-humoral derangements during volume expansion.

Cite This Study

Borghi et al. (1993) studied this question.

synapsesocial.com/papers/6a6f92c784cc45bb7bdfa3b4https://doi.org/10.3109/10641969309032938

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blunting of atrial natriuretic factor response to volume expansion by benazepril in hypertensive patients1989 · 5 citations
  2. 2Reduction of atrial natriuretic factor circulating levels by endogenous sympathetic activation in hypertensive patients.1988 · 27 citations
  3. 3Importance of Plasma Renin Activity Suppression and Venous Distensibility on Pressor and Natriuretic Responses to Intravenous Salt Load in Borderline Hypertension1988 · 6 citations
  4. 4Effect of Captopril on the Blood Pressure and Renal Responses to Acute Saline Loading in Normal and Essential Hypertensive Subjects1982 · 6 citations
  5. 5Cardiopulmonary Blood Volume in Borderline Hypertension1974 · 58 citations