Reduction of atrial natriuretic factor circulating levels by endogenous sympathetic activation in hypertensive patients.
Why the study?
Does endogenous sympathetic activation reduce plasma levels of atrial natriuretic factor in patients with essential hypertension?
Population
Subjects with essential hypertension
Comparison
Endogenous sympathetic activation reflex-induced… vs Baseline and adrenergic blockade
Design
Other
Follow-up
15 minutes (acute study)
Authors
Discussion
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Member takes
Implication
May indicate sympathetic suppression of ANF beyond atrial stretch in hypertension; leaves open clinical relevance of non-hemodynamic ANF control.
Structured PICO
Does endogenous sympathetic activation reduce plasma levels of atrial natriuretic factor in patients with essential hypertension?
P
Population
Subjects with essential hypertension
I
Intervention
Endogenous sympathetic activation reflex-induced by selective deactivation of carotid baroreceptors using external neck-tissue pressure (NTP) via a neck chamber
C
Comparator
Baseline and adrenergic blockade (phentolamine + propranolol)
O
Outcome
Plasma levels of immunoreactive atrial natriuretic factor (irANF)surrogate
Endogenous sympathetic activation reduces atrial natriuretic factor release in hypertensive patients, demonstrating that factors other than atrial wall tension influence ANF release.
Cite This Study
Volpe et al. (1988) studied this question.