The pharmaceutical industry faces increasing pressure to minimize its environmental footprint while ensuring product safety and quality. This article provides a comprehensive analysis of current trends, challenges, and best practices related to environmental sustainability in pharmaceutical production. Using a systematic literature review approach, the study examines key areas such as greenhouse gas emissions, water contamination with active pharmaceutical ingredients (APIs), and hazardous waste management. The findings reveal that large companies in developed countries are leading the adoption of green chemistry principles and life cycle assessment (LCA), driven by regulatory frameworks and financial resources, while producers in emerging economies struggle with inadequate waste management infrastructure and regulatory enforcement. The paper also explores regulatory influences, technological innovations, and digitalization as enablers of sustainable practices. Solutions such as process optimization, renewable energy adoption, solvent recovery, and integration of artificial intelligence in production processes are highlighted as essential for reducing the sector’s ecological impact. This review identifies research gaps and provides recommendations for aligning pharmaceutical manufacturing with global sustainability goals.
Miraute et al. (Tue,) studied this question.