Mechanisms and Clinical Implications of Allergy- Assisted Immunotherapy for Tumor Neurogenesis

Tumor neurogenesis—the growth of new nerve fibers within solid tumors—plays a pivotal role in cancer progression, metastasis, and immune escape by fostering a supportive neural microenvironment. Traditional immunotherapies often falter against these neural networks, limiting their therapeutic impact. Emerging research points to allergy-assisted cancer immunotherapy (AACI), particularly leveraging acute IgE-mediated allergic responses, as a disruptive approach to sever nerve-tumor crosstalk. By inducing localized allergic inflammation, AACI can transform immunologically "cold" tumors into "hot" ones that are more susceptible to immune attack. This review synthesizes mechanistic insights, preclinical advances, and clinical potential for AACI as a next-generation strategy to overcome immune resistance and improve outcomes for patients with solid cancers.