Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 13, 2026Nature CommunicationsOpen Access

Structural basis for positive allosteric regulation of CB2 receptor

View Full Paper
Ask AI
Bookmark
Share

Authors

XWXuehui WangYCYe CaiXYXin Yang

Discussion

Loading...

Member takes

Overview

Structural analysis reveals a positive allosteric modulator enhances CB2 receptor activation linked to neuropathic pain treatment.

Key Points

  • To understand the structural mechanism underlying the positive allosteric modulation of the CB2 receptor.
  • Resolved the cryo-EM structure of CB2 with PAM Ec21a and agonist CP55940
  • Conducted structural analysis and cell functional experiments
  • Assessed allosteric effects of Ec21a in combination with various agonists.
  • Ec21a significantly enhances activation efficiency of CP55940
  • Ec21a binds to a unique site, increasing the interaction with CB2
  • Findings provide guidance for designing bitopic ligands targeting CB2.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a03cc3d1c527af8f1ed010bhttps://doi.org/10.1038/s41467-026-72923-6
View Full Paper
Ask AI
Bookmark
Share