Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 26, 2026British Journal of PharmacologyOpen Access

Cannabinoid CB 1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

View Full Paper
Ask AI
Bookmark
Share

Authors

ISIfeoluwa D. SolomonSGSumanta GaraiGTGanesh A. Thakur

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates CB1 allosteric ligands’ efficacy in pain management, suggesting safer alternatives.

Key Points

  • This research aims to evaluate the efficacy of CB1 allosteric ligands in managing inflammatory pain without associated side effects.
  • Evaluated GAT228 and GAT229 in male mice with CFA-induced inflammatory pain.
  • Assessed tolerance, memory deficits, motor impairment, and respiratory depression against CP55,940.
  • Conducted behavioral tests including mechanical hypersensitivity and novel object recognition.
  • GAT228 and GAT229 reduced mechanical hypersensitivity without tolerance or hypothermia.
  • CP55,940 caused memory deficits, motor impairment, and respiratory depression, which allosteric ligands did not.
  • Allosteric ligands normalized pain-related behavioral despair, contrary to effects observed with CP55,940.

Cite This Study

Solomon et al. (2026) studied this question.

synapsesocial.com/papers/6a65a422d3aea3239cd76e68https://doi.org/10.1111/bph.70572
View Full Paper
Ask AI
Bookmark
Share