What question did this study set out to answer?

To evaluate whether cytomegalovirus seropositivity is associated with all-cause and cardiovascular disease-related mortality in a nationally representative population and assess whether C-reactive protein mediates or modifies these relationships.

February 17, 2011PLoS ONEOpen Access

Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

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Authors

ASAmanda M. SimanekRosalind Franklin University of Medicine and Science JDJennifer B. DowdLeverhulme Trust GPGraham PawelecNational Institutes of Health

Discussion

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Implication

Prospective cohort study uncovers increased all-cause mortality in adults with cytomegalovirus, suggesting a hazardous synergy between chronic viral infection and systemic inflammation.

Key Points

To evaluate whether cytomegalovirus seropositivity is associated with all-cause and cardiovascular disease-related mortality in a nationally representative population and assess whether C-reactive protein mediates or modifies these relationships.
Analyzed data from the third National Health and Nutrition Examination Survey (NHANES III, 1988–1994) with mortality follow-up through December 31, 2006 (N = 14,153 participants aged ≥ 25 years).
Assessed cytomegalovirus serostatus and C-reactive protein (CRP) levels using Cox proportional hazard models adjusting for multiple confounders.
Cytomegalovirus seropositivity was significantly associated with increased all-cause mortality (HR 1.19, 95% CI: 1.01, 1.41) after adjusting for confounders, whereas the association with CVD-related mortality was not statistically significant.
CRP did not mediate the association; however, seropositive individuals with high CRP levels exhibited a 30.1% higher risk for all-cause mortality and a 29.5% higher risk for CVD-related mortality compared to seropositive individuals with low CRP levels.

Cite This Study

Simanek et al. (2011) studied this question.

synapsesocial.com/papers/6a03efce50d3ed7cf32b3799 https://doi.org/10.1371/journal.pone.0016103

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Implication

Prospective cohort study uncovers increased all-cause mortality in adults with cytomegalovirus, suggesting a hazardous synergy between chronic viral infection and systemic inflammation.

Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

Discussion

Member takes

Implication

Key Points

Cite This Study

Seropositivity to Cytomegalovirus, Inflammation, All-Cause and Cardiovascular Disease-Related Mortality in the United States

Discussion

Member takes

Implication

Key Points

Cite This Study

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