Why the study?
Does increased potassium intake alter adrenal cortical and cardiovascular responses to Angiotensin II in healthy normotensive men?
Does increased potassium intake alter adrenal cortical and cardiovascular responses to Angiotensin II in healthy normotensive men?
In healthy normotensive men, increased potassium intake potentiates AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics.
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Potassium may heighten aldosterone in high-AngII states without hemodynamic effects; extends RAAS physiology in normotensives.
=0.0020). In contrast, the hemodynamic responses (blood pressure, total peripheral resistance, cardiac output, and renal artery blood flow) to AngII were similar after potassium and placebo. Conclusions Increased potassium intake potentiates AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men. Registration EudraCT Number: 2013-004460-66; URL: https://www.ClinicalTrials.gov; Unique identifier: NCT02380157.
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Dreier et al. (2021) studied this question.
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