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This review aims to summarize the techniques for isolating and purifying κ-casein glycomacropeptide (GMP) from dairy sources.

Isolation and purification of κ-casein glycomacropeptide: A review

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This review aims to summarize the techniques for isolating and purifying κ-casein glycomacropeptide (GMP) from dairy sources.
Discusses methods of ultrafiltration and deproteinization for whey treatment.
Covers chromatographic techniques with a focus on anion exchange chromatography for GMP purification.
Highlights laboratory methods achieving high-purity GMP using combined dialysis and chromatographic techniques.
Achievable GMP purification devoid of phenylalanine and tyrosine, suitable for dietary management of specific disorders.
Identified anion exchange chromatography as effective for selectively adsorbing GMP.
Suggests future research on producing GMP from industrial by-products like second cheese whey.

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Review discusses techniques for isolating glycomacropeptide from whey to help treat genetic disorders.

Nakano et al. (2026) studied this question.

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