Synthesis of pyrazolo[5,1-a]isoindoles via silver-mediated cascade cyclization of 1,5-enynes with diazo compounds

Jiarong Li; He Wang; Chunbo Li; Jing Sun; Xin Wang; Ran Sun; Lei Li

doi:10.1039/d6cc01160h

January 1, 2026Chemical Communications

Synthesis of pyrazolo[5,1-a]isoindoles via silver-mediated cascade cyclization of 1,5-enynes with diazo compounds

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Key Points

The aim is to develop an efficient method for synthesizing pyrazolo[5,1-a]isoindoles from simple precursors.
Utilized a silver-mediated cascade cyclization reaction.
Reacted 1,5-enynes with diazo compounds in a one-pot process.
Constructed two rings and three new bonds efficiently.
Successfully synthesized pyrazolo[5,1-a]isoindoles from acyclic precursors.
Achieved efficient formation of multiple rings and bonds in a single reaction.
Demonstrated potential for broader applications in synthetic organic chemistry.

Implication

Demonstrates effective synthesis of pyrazolo[5,1-a]isoindoles from acyclic precursors, suggesting a novel synthetic pathway.

Abstract

Herein, we report a silver-mediated cascade cyclization of 1,5enynes with diazo compounds for the direct synthesis of pyrazolo[5,1-a]isoindoles from simple acyclic precursors. This onepot process forges two rings and three...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a0414cc79e20c90b4444aea https://doi.org/10.1039/d6cc01160h

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Synthesis of pyrazolo[5,1-a]isoindoles via silver-mediated cascade cyclization of 1,5-enynes with diazo compounds

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of pyrazolo[5,1-a]isoindoles via silver-mediated cascade cyclization of 1,5-enynes with diazo compounds

Key Points

Implication

Abstract

Discussion

Cite This Study

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