Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

Yangxin Mao; Shaotong Qiu; Xinlei Wang; Yimin Shangguan; Jiangan Liu; Zhicheng Yang; Yun-Hui Zhao; Xiaofang Li; Baishu Zheng; Hu Zhou

doi:10.1039/d6cc00525j

January 1, 2026Chemical Communications

Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

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Key Points

The research aims to develop a catalyst-free method for synthesizing pyrazolo[5,1-a]isoquinolines using enynones and hydrazine.
Used enynone and unprotected hydrazine in a cyclization reaction.
Implemented simple reaction conditions for synthesis.
Evaluated a variety of substrates to test the breadth of application.
Achieved high efficiency in synthesizing products.
Demonstrated a broad substrate scope with diverse enynone types.
Confirmed the practical utility of the synthetic method.

Implication

This research demonstrates a catalyst-free synthesis of pyrazolo[5,1-a]isoquinolines from hydrazine, indicating practical applications in organic chemistry.

Abstract

An unprecedented catalyst-free cyclization reaction of easily accessed enynone and unprotected hydrazine is reported. Featuring simple reaction conditions, high efficiency and broad substrate scope, this protocol provides a practical synthetic...

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Cite This Study

Mao et al. (2026) studied this question.

synapsesocial.com/papers/69c37b54b34aaaeb1a67d959 https://doi.org/10.1039/d6cc00525j

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Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

Key Points

Implication

Abstract

Discussion

Cite This Study

Catalyst-free Synthesis of Pyrazolo[5,1-a]isoquinolines from Hydrazine Hydrate

Key Points

Implication

Abstract

Discussion

Cite This Study

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