Catalyst-free Synthesis of Pyrazolo5,1-aisoquinolines from Hydrazine Hydrate

Key Points

• The research aims to develop a catalyst-free method for synthesizing pyrazolo[5,1-a]isoquinolines using enynones and hydrazine.
• Used enynone and unprotected hydrazine in a cyclization reaction.
• Implemented simple reaction conditions for synthesis.
• Evaluated a variety of substrates to test the breadth of application.
• Achieved high efficiency in synthesizing products.
• Demonstrated a broad substrate scope with diverse enynone types.
• Confirmed the practical utility of the synthetic method.