Evaluates metabolic stability of vardenafil in human liver microsomes, suggesting improvements in drug design.
The current UPLC-MS/MS method is considered the first analytical method for vardenafil quantification in the HLMs matrix. Small changes to the 4-ethylpiperazine ring in drug design could improve the metabolic stability of new vardenafil derivatives.
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Attwa et al. (2026) studied this question.
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