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This analysis demonstrates metabolic stability in human liver microsomes, suggesting in silico findings can guide drug design improvements.
An UPLC-MS/MS method was established for assessing avapritinib in HLMs matrix. In silico analysis suggests that minor structural changes to the methyl pyrazole moiety in drug design may improve the metabolic stability relative to avapritinib.
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Attwa et al. (2025) studied this question.
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