Quantitative method measures saracatinib levels in human liver microsomes, suggesting drug design improvements for stability.
The hydrophilic interaction UPLC-MS/MS method was used for the quantification of saracatinib in HLMs. Small changes to the N -methyl piperazine in drug design might improve the metabolic stability of new derivatives compared with that of saracatinib.
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Attwa et al. (2026) studied this question.
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