What question did this study set out to answer?

The aim is to quantify saracatinib in human liver microsome matrices and assess metabolic stability.

February 12, 2026Analytical Methods1 citations

A hydrophilic interaction UPLC-MS/MS quantitative method for the quantification of saracatinib in the human liver microsome matrix and its application in in vitro metabolic stability assessment

MAMohamed W. AttwaKing Saud University AKAdnan A. KadiKing Saud University

Key Points

The aim is to quantify saracatinib in human liver microsome matrices and assess metabolic stability.
Employs a hydrophilic interaction UPLC-MS/MS technique.
Assesses saracatinib levels in human liver microsomes.
Investigates structural modifications to enhance metabolic stability.
Successful quantification of saracatinib in the HLM matrix.
Minor structural changes may lead to better metabolic stability in new derivatives.

Abstract

The hydrophilic interaction UPLC-MS/MS method was used for the quantification of saracatinib in HLMs. Small changes to the N -methyl piperazine in drug design might improve the metabolic stability of new derivatives compared with that of saracatinib.

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