Quantitative method reveals low extraction ratio of veliparib in human liver microsomes, indicating potential metabolic stability and safety improvements.
Veliparib exhibited a relatively slow extraction ratio, with a low Cl int of 22.23 mL min −1 kg −1 and a long t 1/2 of 36.48 min. Minor replacements within the pyrrolidine ring (96%) in veliparib may increase the metabolic stability and safety profile.
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Attwa et al. (2025) studied this question.
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