Proposed framework redefines learning and cognition through microtubules and ephaptic fields, suggesting a new understanding of brain function.
Classical neuroscience views the brain as a simple electrochemical wiring board, but this model struggles to explain the speed and energy efficiency of human cognition. We propose a paradigm-shifting biophysical framework: the "Holographic Transceiver." In this architecture, the structural scaffolding inside neurons—the microtubule network—functions as an adaptive electromechanical resonator. Rather than merely supporting the cell, these cytoskeletal bundles actively couple to the brain's macroscopic electromagnetic (ephaptic) fields. When a bundle's physical geometry resonates with the local phase gradient of an incoming brainwave, it triggers targeted synaptic firing. Learning is thereby redefined: enzymes like CaMKII physically alter the microtubule lattice, continuously re-calibrating the structural geometry to match specific field-encoded memory states. By bridging quantum optics, thermodynamics, and mechanotransduction, this model successfully explains how global cognitive fields drive precise mechanical actions without violating local thermodynamic constraints.
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David Samuel Remba Uribe (2026) studied this question.
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