A Contemporary View on Kimura Disease

Kimura disease is a rare, chronic inflammatory disorder of unclear etiology, characterized by peripheral eosinophilia, elevated serum IgE levels, and the development of subcutaneous nodules, most commonly located in the head and neck region. This review aims to summarize the current understanding of the disease, including its etiology, pathogenesis, clinical presentation, histopathological features, and diagnostic criteria. Particular emphasis is placed on the differential diagnosis with angiolymphoid hyperplasia with eosinophilia, as well as other conditions associated with lymphadenopathy and eosinophilia. Contemporary therapeutic approaches are also discussed, including surgical management, corticosteroid therapy, immunosuppressive agents, and alternative treatment modalities. Awareness of the clinical and histopathological features of Kimura disease is essential for accurate diagnosis and appropriate therapeutic decision-making.