Key result
Polycystic ovary syndrome linked to increased carotid intima-media thickness and higher serum omentin-1.
Why the study?
The study was designed to investigate whether polycystic ovary syndrome is related to levels of omentin-1 and carotid intima-media thickness, and to demonstrate their association with cardiovascular risk.
Is polycystic ovary syndrome associated with increased levels of omentin-1 and carotid intima-media thickness compared to healthy subjects?
Case-Control (n=82)
Is polycystic ovary syndrome associated with increased levels of omentin-1 and carotid intima-media thickness compared to healthy subjects?
Patients with PCOS show increased carotid intima-media thickness and elevated serum omentin-1 levels, indicating early signs of cardiovascular risk.
May prompt earlier CV risk evaluation in PCOS; leaves open omentin-1's mechanistic role.
AIM: Omentin-1, an adipokine primarily secreted from visceral adipose tissue, regulates metabolic homeostasis, whereas carotid intima-media thickness (CIMT) is a valid marker for early diagnosis of atherosclerosis. We aimed to investigate whether polycystic ovary syndrome (PCOS) is related to levels of omentin-1 and CIMT and demonstrate the association with cardiovascular risk. METHODS: A prospective case-control study was performed on 47 PCOS patients and 35 healthy subjects. Hormonal and metabolic parameters, levels of serum omentin-1, and CIMT were evaluated in the two groups. RESULTS: (p < 0.001 for all comparisons). CONCLUSION: A significant increase in CIMT is associated with cardiovascular risk in patients with PCOS. Levels of serum omentin-1 were found to be significantly higher in early PCOS cases at a younger age, acting as a protective acute-phase reactant.
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Tosun et al. (2021) conducted a case-control in Polycystic ovary syndrome (n=82). Polycystic ovary syndrome vs. Healthy subjects was evaluated on Levels of serum omentin-1 and carotid intima-media thickness (CIMT) (p=<0.001). Polycystic ovary syndrome was associated with significantly increased carotid intima-media thickness and higher serum omentin-1 levels compared to healthy subjects (p < 0.001).
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