Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

Alessia Gagliardi; Vanessa Porter; Zusheng Zong; Reanne Bowlby; Emma Titmuss; Constance Namirembe; Nicholas B. Griner; Hilary Petrello; Jay Bowen; Simon K. Chan; Luka Culibrk; Teresa M. Darragh; Mark H. Stoler; Thomas C. Wright; Patee Gesuwan; Maureen A. Dyer; Yussanne Ma; Karen Mungall; Steven J.M. Jones; Carolyn Nakisige; Karen Novik; Jackson Orem; Martin Origa; Julie M. Gastier‐Foster; Robert Yarchoan; Corey Casper; Gordon B. Mills; Janet S. Rader; Akinyemi I. Ojesina; Daniela S. Gerhard; Andrew J. Mungall; Marco A. Marra

doi:10.1038/s41588-020-0673-7

Key Points

This research aims to explore the epigenomic and transcriptomic differences in cervical carcinomas related to specific human papillomavirus (HPV) clades.
Analyzed epigenetic modifications across multiple cervical tumor samples.
Conducted extended mutation analysis involving a total of 89 tumors.
Investigated the correlation between histone modifications and gene expression.
Identified HPV-clade-specific differences in tumor DNA methylation and histone marks.
Found upregulation of nearby genes associated with HPV integration events.
Noted changes in pathway dysregulation linked to these epigenomic alterations.

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Implication

Analysis identifies HPV-clade-specific epigenome alterations in cervical tumors, suggesting potential biomarkers for cancer therapies.

Abstract

, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA methylation, promoter- and enhancer-associated histone marks, gene expression and pathway dysregulation. Changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses.

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Gagliardi et al. (2020) studied this question.

synapsesocial.com/papers/6a050146d6c05e8e9519c2f0 https://doi.org/10.1038/s41588-020-0673-7

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Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

Key Points

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Cite This Study

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes

Key Points

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Implication

Abstract

Discussion

Cite This Study

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