October 18, 2024Journal of the American Heart Association14 citationsOpen Access
Left Ventricular Ejection Fraction Change Following Percutaneous Coronary Intervention: Correlates and Association With Prognosis
Key Result
Improvement in LVEF following PCI was associated with reduced long-term cardiac death in patients with reduced baseline LVEF (P<0.001 per 5% higher ΔLVEF).
Study Design
Type
Observational
Structured PICO
Does left ventricular ejection fraction (LVEF) change following percutaneous coronary intervention predict long-term mortality in patients with coronary artery disease?
P
Population
8,181 patients with angiographic coronary artery disease who underwent percutaneous coronary intervention (PCI) with coronary stenting for de novo coronary atherosclerotic lesions and had paired angiographic LVEF measurements at baseline and 6 to 8 months. Excluded: advanced renal failure on dialysis, cardiogenic shock, or previous cardiac transplantation.
I
Intervention
Percutaneous coronary intervention (PCI) with coronary stenting (bare-metal or drug-eluting stents) followed by standard medical therapy including aspirin and a platelet adenosine diphosphate receptor inhibitor.
O
Outcome
Death of any cause at 5 yearshard clinical
Improvement in LVEF following PCI is associated with reduced long-term mortality in patients with reduced baseline LVEF, but not in those with preserved baseline LVEF.
Main Result
p-value: p=<0.001
Abstract
BACKGROUND: The association between left ventricular ejection fraction (LVEF) change (ΔLVEF) following percutaneous coronary intervention (PCI) and the long-term mortality rate in patients with coronary artery disease is incompletely investigated. We aimed to assess the impact of PCI on LVEF and the association of ΔLVEF after PCI with the long-term mortality rate. METHODS AND RESULTS: <0.001) for cardiac death, calculated for 5% higher ΔLVEF. CONCLUSIONS: In patients with coronary artery disease undergoing PCI, improvement of LVEF following PCI was associated with a reduced long-term mortality rate in patients with reduced LVEF but not in patients with preserved LVEF before intervention.